Amy Lee is a singer-songwriter and pianist, as well as an epilepsy advocate. She is the co-founder and lead singer of the rock band Evanescence, which is known for its hit song, "My Immortal." Lee is the American chairperson for the international epilepsy awareness foundation Out of the Shadows.

Her brother Robby struggled with severe epilepsy for most of his life, eventually dying in 2018. Along with her contributions with the band, Lee has also participated in other musical projects including Walt Disney Records' Nightmare Revisited and Muppets: The Green Album.

She has performed collaborations with artists such as Korn, Seether, and David Hodges. Lee composed the soundtrack to the films War Story (2014) and Indigo Grey: The Passage (2015) with cellist Dave Eggar, and the song "Speak to Me" for the 2017 film Voice from the Stone.

Lee received the Songwriter Icon Award from the National Music Publishers Association in 2008. In 2012, she won Best Vocalist at the Revolver Golden Gods Awards and was also named Rock Goddess of the Year at the Loudwire Music Awards.

She was awarded Best Film Score by the Moondance International Film Festival for Indigo Grey: The Passage in 2015. Lee is also known for her sense of style, having been called a "gothic rock superstar" due to her fondness for Gothic makeup and Victorian-styled clothing.