Guilherme Arantes has had success with his interpretations for hits like "Meu Mundo e Nada Mais," "Planeta Água," "Cheia de Charme," "Coisas do Brasil," and others, all written by him with different partners.

His songs also had success in the interpretation of other artists like Elis Regina, Caetano Veloso, Roberto Carlos, Cláudia Telles, Gang 90, Biafra, Ana Belém, Quarteto em Cy, Jessé, Cauby Peixoto, Belchior, Ney Matogrosso, Luiz Ayrão, Sandra Sá, MPB-4, Fafá de Belém, A Cor do Som, Vanusa, Zizi Possi, Joanna, Eliete Negreiros, Emílio Santiago, Barão Vermelho, Os Cariocas, 14 Bis, Flávio Venturini, Verônica Sabino, Ná Ozetti, Pena Branca & Xavantinho, Nenhum de Nós, Klébi, Chitãozinho e Xororó, Maria Bethânia, Leila Pinheiro, Sá e Guarabira, and others.

His compositions also have been included in more than 20 soap opera soundtracks.