Michael Santiago Render, known by his stage name, Killer Mike, is a rapper, actor, and activist. He is the founder of Grind Time Official Records, which he launched through the SMC and Fontana Distribution.

Mike made his debut on "Snappin' and Trappin'" from OutKast's 2000 LP Stankonia and later appeared on the Grammy-winning song "The Whole World," a single from Outkast's greatest hits album Big Boi and Dre Present.

..Outkast. He has since released several full-length albums as a solo artist. In December 2008, Mike signed to fellow Atlanta-based rapper T.I.'s Grand Hustle Records. In 2012, he released R.A.P. Music, produced entirely by American rapper and producer El-P.

Killer Mike and El-P subsequently formed a duo in 2013, branding themselves Run the Jewels; the duo was signed to Fool's Gold Records and released their self-titled debut in June of that year. Killer Mike is also known as a social and political activist, focusing on subjects including social inequality, police brutality, and systemic racism.

In addition to addressing themes of racism and police brutality in his music, he has also delivered several lectures at colleges and universities, written about social justice topics for publications such as Billboard, and been the subject of televised and published interviews regarding police misconduct and race relations.

He was a visible and vocal supporter of Bernie Sanders during his 2016 U.S. presidential campaign and refused to support Hillary Clinton after Sanders left the race. Killer Mike has been featured in the films 20 Funerals, Idlewild, Baby Driver, and ATL.

In January 2019, his Netflix documentary series, titled "Trigger Warning with Killer Mike," premiered.